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Abstract

Obesity and the Maternal Lipid Profile Role of Diet in Epigenetic Transfer on the Offsprings

Aim: /nvÄ?ƐÆ?ŐÄ?Æ?Ä? the ŝmÆ?ůŝcÄ?Æ?ŽnƐ of High Fat Diet (HFD) induced obesity on the lipid Æ?rŽĮůÄ? in parent rats and their ŽīƐÆ?rŝnŐÍ? Methodology: Twenty adult female rats were grouped into A and B which received NRC and HFD rÄ?ƐÆ?Ä?cÆ?vÄ?ůy for 16 obese. Adult male Wistar rats fed with NRC were introduced to each group to ensure mÄ?Æ?nŐ and pregnancy Ä?Å?Ä?r feeding. The ŽīƐÆ?rŝnŐ produced by the rats in each group were divided into two groups of 20 rats each. They were fed with NRC for 12 months. The plasma obtained from the parent and ŽīƐÆ?rŝnŐ were analysed for lipid Æ?rŽĮůÄ? test. Results: The parent rats fed with HFD had higher cholesterol triglyceride and HDL compared with the rats fed with NRC. At 4 and 12 months the ŽīƐÆ?rŝnŐ of HFD fed rats had lower triglyceride and LDL compared with ŽīƐÆ?rŝnŐ of NRC fed rats. The ŽīƐÆ?rŝnŐ of HFD fed rats had higher HDL compared with the ŽīƐÆ?rŝnŐ of NRC fed rats at 8 months. Conclusion: KīƐÆ?rŝnŐ of obese HFD fed rats placed on NRC did not manifest the consequence of maternal obesity as depicted by their lipid Æ?rŽĮůÄ?Í?


Author(s):

Ogundipea OJ, Akomolafe RO , Olukiran OS and Akinpelu OF



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